Welcome to NIPS!

 

A 3D-network integrated disease risk prediction method for SAP.

Human Uniprot Accession:

For example: P22455, Q9Y6R0

    

How to use NIPS to search cancer driver SAPs

 

NIPS is an integrated method to predict the deleterious singular amino acid change (SAP) in human cancer. We assume that a single amino acid polymorphism (SAP) may have a deleterious effect if: it rarely occurs naturally, based on sequence and evolutionary information; or it inhibits binding between a pair of interacting proteins when it lies at their interface; or the mutant protein plays an important role in a protein-protein interaction network. Thereby we use three scores to evaluate these properties: S-score, I-score and T-score. Finally, a weighted average score is used to integrate these three scores a meta-score. User may search your interested protein. Now it supports Uniprot protein for query only(http://www.uniprot.org/). In the querying results, the known SAPs detected in cancers previously with the meta-score and each individual score will be given in a prioritized list sorting by meta-scores. User also can post a new SAP for the queried protein in the search box.

 

The Cutoffs: Meta-score: 0.57 S-score: 0.95 I-score: 1 T-score: 0.90