UniProt ID P27361
Protein Name Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulat
ed kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associa
ted protein 2 kinase) (p44-ERK1)
Gene Name MAPK3
Position 202
SequenceWindow HDHTGFLTEYVATRW
Function Score? 0.998
Disorder score? 0.162 Ordered
Protein-Targeted Drug

BVD-523; HH2710; ASTX029; ASN007; VAN-10-4-eluting stent; GDC-0994; JSI-1187; COR-D; 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine; Sulindac; Acetylsalicylic acid; Minocycline; Arsenic trioxide; Colforsin; Purvalanol; 5-iodotubercidin; Seliciclib; Cholecystokinin; Ulixertinib; MADOLIN A; PTHRP; ULIXERTINIB; METHYLNITROSOUREA; QUERCETIN; VOLVALERENAL D; ETOPOSIDE; CHEMBL:CHEMBL2088730; CHEMBL:CHEMBL2088731; RAVOXERTINIB; CHEMBL:CHEMBL2333548; CIMIRACEMATE A; PHENETHYLISOTHIOCYANATE; PRASTERONE; MK-8353; COMBRETASTATIN A4; MADOLIN U; IMMUNOSUPPRESSANT; CHEMBL:CHEMBL329785; CHEMBL:CHEMBL2063687; SPINASAPONIN A METHYL ESTER; CYCLOPHOSPHAMIDE ANHYDROUS; DEMETHYLWEDELOLACTONE; GAMBOGIC AMIDE; SIGNAL TRANSDUCTION INHIBITOR; NITROGLYCERIN; WEDELOLACTONE; WITHAFERIN A; CHEMBL:CHEMBL29197; ARISTOLACTONE; MADOLIN T; SORAFENIB; CHEMBL:CHEMBL2063681; TEMUTERKIB; CHEMBL:CHEMBL389685; YUANHUADINE; CHEMBL:CHEMBL2333543; PESUDOGINSENOSIDE RP1 METHYL ESTER; ARSENIC TRIOXIDE; ASN007; RETINOIC ACID AGENT; N

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Protein Subcellular Localization

Cytoplasm {ECO:0000250|UniProtKB:P21708}. Nucleus. Membrane, caveola {ECO:0000250|UniProtKB:P21708}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q63844}. Note=Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q63844, ECO:0000269|PubMed:19060905}.

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Protein Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP

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Functional domains

Distribution of Tumor Phosphorylation Levels (corrected without protein) in Pan-Cancer

No Data

Distribution of Tumor Phosphorylation Levels (corrected with protein) in Pan-Cancer

No Data

Distribution of Normal Phosphorylation Levels (corrected without protein) in Pan-Cancer

No Data

Distribution of Normal Phosphorylation Levels (corrected with protein) in Pan-Cancer

No Data