Phosphosite: 32 in P98177
| UniProt ID | P98177 |
|---|---|
| Protein Name | Forkhead box protein O4 (Fork head domain transcription factor AFX1) |
| Gene Name | FOXO4 |
| Position | 32 |
| SequenceWindow | QSRPRSCTWPLPRPE |
| Function Score? | 0.998 |
| Disorder score? | 0.758 Disordered |
| Protein-Targeted Drug | - . . . more
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| Protein Subcellular Localization | Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm. . . . more
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| Protein Function | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. . . . more
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| Functional domains |
Distribution of Tumor Phosphorylation Levels (corrected without protein) in Pan-Cancer
Distribution of Tumor Phosphorylation Levels (corrected with protein) in Pan-Cancer
Distribution of Normal Phosphorylation Levels (corrected without protein) in Pan-Cancer
Distribution of Normal Phosphorylation Levels (corrected with protein) in Pan-Cancer
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