UniProt ID Q9P286
Protein Name Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7)
(PAK-7)
Gene Name PAK5
Position 602
SequenceWindow KEVPKRKSLVGTPYW
Function Score? 0.997
Disorder score? 0.256 Ordered
Protein-Targeted Drug

Fostamatinib; HESPERADIN

. . . more
Protein Subcellular Localization

Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

. . . more
Protein Function

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.

. . . more
Functional domains

Distribution of Tumor Phosphorylation Levels (corrected without protein) in Pan-Cancer

No Data

Distribution of Tumor Phosphorylation Levels (corrected with protein) in Pan-Cancer

No Data

Distribution of Normal Phosphorylation Levels (corrected without protein) in Pan-Cancer

No Data

Distribution of Normal Phosphorylation Levels (corrected with protein) in Pan-Cancer

No Data