Phosphosite: 602 in Q9P286
| UniProt ID | Q9P286 |
|---|---|
| Protein Name |
Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) |
| Gene Name | PAK5 |
| Position | 602 |
| SequenceWindow | KEVPKRKSLVGTPYW |
| Function Score? | 0.997 |
| Disorder score? | 0.256 Ordered |
| Protein-Targeted Drug | Fostamatinib; HESPERADIN . . . more
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| Protein Subcellular Localization | Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival. . . . more
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| Protein Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}. . . . more
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| Functional domains |
Distribution of Tumor Phosphorylation Levels (corrected without protein) in Pan-Cancer
Distribution of Tumor Phosphorylation Levels (corrected with protein) in Pan-Cancer
Distribution of Normal Phosphorylation Levels (corrected without protein) in Pan-Cancer
Distribution of Normal Phosphorylation Levels (corrected with protein) in Pan-Cancer
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